Galenkamp K.M.O., Sosicka P., Jung M., Recouvreux M.V., Zhang Y., Moldenhauer M., Brandi G., Freeze H., Commisso C. (2020) Golgi acidification by NHE7 regulates cytosolic pH homeostasis in pancreatic cancer cells. Cancer Discovery, DOI: 10.1158/2159-8290.CD-19-1007.


Lee S-W, Zhang Y., Jung M., Cruz N., Alas B., Commisso C. (2019) EGFR-Pak signaling selectively regulates glutamine deprivation-induced macropinocytosis. Developmental Cell, 50:381-392.


Zhang, Y., Commisso C. (2019) Macropinocytosis in cancer: A complex signaling network. Trends in Cancer, 5(6):332.334.

Commisso, C. (2019) The pervasiveness of macropinocytosis in oncological malignancies. Philosophical Transactions of the Royal Society B: Biological Sciences, 374(1765).


Galenkamp, K.M.O., Alas B., Commisso C. (2019) Quantitation of macropinocytosis in cancer cells. Methods in Molecular Biology, 1928:113-123.


Lee S-W., Alas B., Commisso C. (2019) Detection and quantification of macropinosomes in pancreatic tumors. Methods in Molecular Biology, 1882:171-181.


Commisso, C., Debnath J. (2018) Macropinocytosis fuels prostate cancer. Cancer Discovery, 8(7):800-802.

Recouvreux V.M., Commisso C. (2017) Macropinocytosis: A metabolic adaptation to nutrient stress in cancer. Frontiers in Endocrinology, 8(261):1-7.


Fennell M.*, Commisso C.*, Ramirez C., Garippa R., Bar-Sagi D. (2015) High-Content, full genome siRNA screen for regulators of oncogenic HRAS-driven macropinocytosis. Assay and Drug Development Technologies, 13(7):347-55. *co-first author.


Kamphorst J.J.*, Nofal M.*, Commisso C.*, Hackett S.R., Lu W., Grabocka E., Vander Heiden M.G., Miller G., Drebin J.A., Bar-Sagi D., Thompson C.B., Rabinowitz J.D. (2015) Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Research, 75(3):544-53.  *co-first author


Grabocka E., Commisso C., Bar-Sagi D. (2015) Targeting the dependence of mutant RAS cancers on the DNA damage response. Clinical Cancer Research, 21(5).


Commisso C., Flinn R., Bar-Sagi D. (2014) Determining the macropinocytic index of cancer cells through a quantitative image-based assay. Nature Protocols, 9(1):182-192.


Commisso C., Davidson S.M., Soydaner-Azeloglu R.G., Parker S.J., Kamphorst J.J., Hackett S., Grabocka E., Nofal M., Drebin J.A., Thompson C.B., Rabinowitz J.D., Metallo C.M., Vander Heiden M.G., Bar-Sagi D. (2013) Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.  Nature, 497(7451):633-7.


Liu S., Bonner J., Chanet S., Commisso C., Skwarek L., Schweisguth F., Boulianne G.L. (2012) Functional analysis of the NHR2 domain indicates that oligomerization of Neuralized regulates ubiquitination and endocytosis of Delta during Notch signaling. Molecular and Cellular Biology, 32(24):4933-45.


Commisso C., Boulianne G.L.  (2008) The Neuralized Homology Repeat 1 domain of Drosophila Neuralized mediates nuclear envelope association and Delta-dependent inhibition of nuclear import. Journal of Molecular Biology, 375(4):1125-40.


Skwarek L., Garroni M., Commisso C., Boulianne G.L.  (2007) Neuralized contains a phosphoinositide-binding motif required downstream of ubiquitination for Delta endocytosis and Notch signaling. Developmental Cell, 13(6):783-795.


Commisso C., Boulianne G.L. (2007) The NHR1 domain of Neuralized binds Delta and mediates Delta trafficking and Notch signaling.  Molecular Biology of the Cell, 18(1):1-13.


Rothfels K., Tanny J.C., Molnar E., Friesen H., Commisso C., Segall J. (2005) Components of the ESCRT Pathway, DFG16 and YGR122w are required for Rim101 to act as corepressor with Nrg1 at the Negative Regulatory Element of the DIT1 gene of Saccharomyces cerevisiae. Molecular and Cellular Biology, 25(15):6772-88.


Yeh E., Dermer M., Commisso C., Zhou L., McGlade C.J., Boulianne G.L. (2001) Neuralized functions as an E3 ubiquitin ligase during Drosophila development. Current Biology, 11(21):1675-9.


U.S. Patent Application Serial No. 15,990,030, filed May 25, 2018 for Cancer Diagnostics, Therapeutics, And Drug Discovery Associated With Macropinocytosis (Divisional of U.S. National Patent Application Serial No. 14/009,013, based on PCT International Application No. PCT/US2012/031828, filed April 2, 2012).

Research Highlights and Media Coverage

© 2020 by Cosimo Commisso

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